临床表现 临床表现
Morgan O'Connor1, Mark E Sanderson-Cimino2, Zi Li3
1University of California, San Francisco, Center for Memory and Aging, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
智能手机指控测试可靠地评估神经退行性疾病中的运动和认知障碍. 这些数字工具显示出可扩展,远程监测疾病进展的前景.
科学领域:
- 神经科学是一个神经科学.
- 数字健康数字健康
- 神经学 神经学
背景情况:
- 运动障碍在神经退行性疾病中很普遍.
- 数字健康技术提供了可访问的,低负担的远程运动评估.
- ALLFTD移动应用程序的手指点击测试 (mApp-FTT) 评估了灵巧度.
研究的目的:
- 评估基于智能手机的指控测量的可靠性和构造有效性.
- 评估mApp-FTT性能与临床/运动评估之间的关联.
- 探索mApp-FTT在患有各种神经退行性疾病的个体中的实用性.
主要方法:
- 33名参与者在iOS/Android上完成了mApp-FTT和机械手指点击测试 (FTT).
- 该样本包括患有前性痴呆症谱系障碍,阿尔茨海默氏症痴呆症和其他相关疾病的个体.
- 相关性评估了mApp-FTT与FTT的关联,临床严重程度 (CDR®+NACC-FTLD) 和运动尺度 (PSPRS,UPDRS).
主要成果:
- 在iOS和AndroidmApp-FTT总点击之间有很强的相关性 (r=0.86).
- mApp-FTT显示了与手动FTT,PSPRS,UPDRS和疾病严重程度的显著关联.
- 较差的mApp-FTT性能与较高的四肢刚性, dystonia 和手指敲击缺陷相关.
结论:
- 基于智能手机的手指敲击可以有效地检测运动和认知障碍.
- mApp-FTT显示出作为跟踪疾病进展的可扩展工具的潜力.
- 需要进一步的研究来评估操作系统偏差,并进行纵向验证.
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