生物标志物 生物标志物
Sarah Ko1, Hui Cao2, Mehrshad Saadatinia1
1Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
这项研究使用脑脊液 (CSF) 蛋白质学开发了11个器官特异性蛋白质基生物年龄差距 (ProtBAGs). 大脑和肝脏显示了最准确的衰老预测,推进了多器官衰老模型.
科学领域:
- 生物化学 生化学
- 老年学是指老年学的学科.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 人类的衰老和疾病越来越多地使用多器官框架进行建模.
- 血蛋白质组学是预测生物年龄的关键工具,产生基于蛋白质组的生物年龄差距 (ProtBAG).
- 这项研究利用脑脊液 (CSF) 蛋白质组来扩大器官特定的衰老时钟.
研究的目的:
- 通过使用CSF蛋白质组学数据,推导出11个器官特定的基于蛋白质组的生物年龄差距 (ProtBAGs).
- 应用两个不同的机器学习方法来开发这些器官特定的衰老时钟.
- 评估ProtBAG在不同器官系统中的性能.
主要方法:
- 分析了来自ADNI研究的CSF蛋白质组数据 (7,008种蛋白质,736名参与者).
- 鉴定了器官丰富蛋白质,并训练了两个机器学习模型 (线性SVR和LASSO).
- 通过交叉验证,使用平均绝对误差 (MAE) 和皮尔森相关系数 (r) 来评估模型性能.
主要成果:
- 具有2%缺失率的蛋白质组学归算产生了最好的模型性能 (r2=0.54).
- 大脑和肝脏的ProtBAG显示了最低的平均绝对误差 (MAE) 值,表明更高的准确性.
- 大脑和肝脏的ProtBAG也表现出最高的皮尔森r值,证实了强大的预测能力.
结论:
- 11个器官特异性ProtBAG成功地使用来自ADNI队列的CSF蛋白组进行了开发.
- 这项工作通过基于CSF的多器官洞察来增强现有的器官衰老时钟框架.
- 未来的研究将探索这些新型ProtBAG,认知功能和阿尔茨海默病进展之间的联系.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516