生物标志物 生物标志物
Joshua A Bornhorst1, Chelsea Swartchick1, Prashanthi Vemuri2
1Mayo Clinic, Rochester, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
对慢性病 (CKD) 的阿尔茨海默病 (AD) 生物标志物测量进行调整至关重要. 使用%p-tau217或p-tau217/Aβ42比率可以最大限度地减少功能下降的混效应.
科学领域:
- 神经学和病学 神经学和病学
- 生物标志物发现和验证
背景情况:
- 慢性病 (CKD) 会提高血液中的生物标志物度,这可能会影响阿尔茨海默病 (AD) 的诊断.
- 血化tau217 (p-tau217) 随着AD病理增加,而粉样β1-42 (Aβ42) 则减少.
- 减少估计的膜过率 (eGFR) 对非粉样体个体这些生物标志物的影响需要进行研究.
研究的目的:
- 评估血生物标志物 (p-tau217,np-tau217,Aβ42,Aβ40及其比率) 与降低的EGFR之间的关联.
- 为了确定特定的生物标志物比率是否可以减轻降低功能对AD生物标志物测量的混效应.
主要方法:
- 该研究包括患有CKD第1-4期 (eGFR 25-98) 证实粉样蛋白-PET负的参与者.
- 血生物标志物使用免疫沉质谱学量化.
- 回归分析模拟了eGFR变化对个别生物标志物和计算比率的影响 (%p-tau217,Aβ42/Aβ40,p-tau217/Aβ42).
主要成果:
- 降低EGFR显著增加了预测的血p-tau217 (52%),Aβ42 (16%) 和Aβ40 (19%).
- p-tau217/Aβ42比率和%p-tau217显示较小的预测增加 (分别为31%和19%) 与降低的eGFR.
- Aβ42 / Aβ40比率没有显示预测的增加,这表明它受到EGFR变化的影响较小.
结论:
- %p-tau217和,在较小程度上,p-tau217/Aβ42比率有效地减少了与单独的p-tau217相比,由降低的eGFR引起的混.
- Aβ42和Aβ40也显示了预测增加的减少,EGFR相对于p-tau217.7.相比下降.
- 这些调整的比率为AD生物标志物评估在功能受损的个体中提供了更好的实用性.
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