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相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
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生物标志物 生物标志物

Joshua A Bornhorst1, Chelsea Swartchick1, Prashanthi Vemuri2

  • 1Mayo Clinic, Rochester, MN, USA.

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|December 25, 2025
PubMed
概括

对慢性病 (CKD) 的阿尔茨海默病 (AD) 生物标志物测量进行调整至关重要. 使用%p-tau217或p-tau217/Aβ42比率可以最大限度地减少功能下降的混效应.

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科学领域:

  • 神经学和病学 神经学和病学
  • 生物标志物发现和验证

背景情况:

  • 慢性病 (CKD) 会提高血液中的生物标志物度,这可能会影响阿尔茨海默病 (AD) 的诊断.
  • 血化tau217 (p-tau217) 随着AD病理增加,而粉样β1-42 (Aβ42) 则减少.
  • 减少估计的膜过率 (eGFR) 对非粉样体个体这些生物标志物的影响需要进行研究.

研究的目的:

  • 评估血生物标志物 (p-tau217,np-tau217,Aβ42,Aβ40及其比率) 与降低的EGFR之间的关联.
  • 为了确定特定的生物标志物比率是否可以减轻降低功能对AD生物标志物测量的混效应.

主要方法:

  • 该研究包括患有CKD第1-4期 (eGFR 25-98) 证实粉样蛋白-PET负的参与者.
  • 血生物标志物使用免疫沉质谱学量化.
  • 回归分析模拟了eGFR变化对个别生物标志物和计算比率的影响 (%p-tau217,Aβ42/Aβ40,p-tau217/Aβ42).

主要成果:

  • 降低EGFR显著增加了预测的血p-tau217 (52%),Aβ42 (16%) 和Aβ40 (19%).
  • p-tau217/Aβ42比率和%p-tau217显示较小的预测增加 (分别为31%和19%) 与降低的eGFR.
  • Aβ42 / Aβ40比率没有显示预测的增加,这表明它受到EGFR变化的影响较小.

结论:

  • %p-tau217和,在较小程度上,p-tau217/Aβ42比率有效地减少了与单独的p-tau217相比,由降低的eGFR引起的混.
  • Aβ42和Aβ40也显示了预测增加的减少,EGFR相对于p-tau217.7.相比下降.
  • 这些调整的比率为AD生物标志物评估在功能受损的个体中提供了更好的实用性.