Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

516
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
516
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

295
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
295
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

358
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
358
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

430
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
430
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

647
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
647
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

433
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
433

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mortality trends associated with hypertension and atrial fibrillation: A CDC WONDER data analysis.

Global epidemiology·2025
Same author

Patterns and trends in prevalent central nervous system stimulant use in US veterans with traumatic brain injury.

The American journal of medicine·2025
Same author

Barriers and facilitators of antiseizure medication adherence: a qualitative study among persons with epilepsy in Pakistan.

BMC neurology·2025
Same author

Medication therapy management in Pakistan: a cross-sectional evaluation of pharmacists' knowledge, attitudes, practices, and barriers.

Journal of pharmaceutical health care and sciences·2025
Same author

Periocular clinical differences between primary and postparalytic hemifacial spasm: A retrospective comparative study.

Indian journal of ophthalmology·2025
Same author

Integrating socio-behavioral, ethics, community, and translational science considerations in HIV cure research.

Current opinion in HIV and AIDS·2025
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

临床表现 临床表现

Mo-Kyung Sin1, Richard M Allman2, Charles Faselis3

  • 1Seattle University, Seattle, WA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

即使微小心理状态检查 (MMSE) 评分在正常范围内略有下降,也与老年人患阿尔茨海默病和相关痴呆症 (ADRD) 的风险更高有关. 这一发现表明,MMSE可以帮助识别有针对性的ADRD预防的个人.

更多相关视频

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

相关实验视频

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

科学领域:

  • 老年学是一门学科.
  • 神经学 神经学
  • 公共卫生 公共卫生

背景情况:

  • 认知功能受损是阿尔茨海默病和相关痴呆症 (ADRD) 的已知危险因素.
  • 老年人中正常范围的迷你精神状态检查 (MMSE) 评分 (27-30) 和ADRD风险之间的关联尚未得到充分理解.

研究的目的:

  • 调查正常认知功能之间的关系,按MMSE27-30的得分测量,以及社区生活的老年人患ADRD的风险.
  • 要确定MMSE得分在正常范围内下降是否是ADRD的独立预测因素.

主要方法:

  • 从心血管健康研究 (CHS) 中分析了4433名社区老年人 (≥65岁) 的数据,这些老年人具有正常的基线认知功能 (MMSE 27-30).
  • 基线特征和事件ADRD在MMSE分数30,29,28和27的基线特征和事件ADRD的比较.
  • 使用多变量Cox比例危险模型来评估MMSE得分 (29,28,27) 和事件ADRD之间的关联,MMSE30作为参考,对27个共变量进行调整.

主要成果:

  • 与MMSE 30 (p < 0.001) 相比,较低正常MMSE分数 (27-29) 的参与者年龄较大,在日常生活活动 (ADL) 障碍方面得分较高.
  • 事件ADRD的调整危险比率随着MMSE得分的下降而逐渐增加:MMSE 29的1.42,MMSE 28的1.71和MMSE 27的1.92,与MMSE 30相比 (p <0.001对所有).
  • 年龄,BMI,糖尿病,抑郁症和吸烟也是ADRD的重要预测因素.

结论:

  • 在MMSE得分从30下降,即使在正常范围内,也与老年人患ADRD的风险增加和独立风险显著相关.
  • 对于具有正常认知能力的风险分层老年人来说,MMSE可以是一个有价值的工具,使得有针对性的ADRD预防策略成为可能.