Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

MeLSI: Metric Learning for Statistical Inference in microbiome community composition analysis.

mSystems·2026
Same author

The prevalence and incidence of delirium superimposed on dementia in community settings: A systematic review and meta-analysis.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

A 98-qubit trapped-ion quantum computer with all-to-all connectivity.

Nature·2026
Same author

Pulmonary embolism in inflammatory bowel disease: competing risks at the bedside.

Proceedings (Baylor University. Medical Center)·2026
Same author

Stroke-induced gut microbiome dysbiosis accelerates Alzheimer's disease progression.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

AI-enabled digital wound monitoring after cardiac surgery: a randomised controlled feasibility, safety, and acceptability trial.

The Journal of hospital infection·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

基础科学和病原发生学

Maalavika Govindarajan1, Chetan Aware1, Kira Ivanich1

  • 1University of Missouri, Columbia, MO, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

诱导性氧化合成酶淘汰 (iNOS-KO) 可能在阿尔茨海默氏症 (AD) 模型中保护大脑血流 (CBF). 这种神经保护作用仍然存在,尽管由从轻度认知障碍 (MCI) 患者的便微生物组移植 (FMT) 引起的肠道失调.

更多相关视频

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

相关实验视频

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

科学领域:

  • 神经科学是一个神经科学.
  • 微生物学 微生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 诱导性氧化合成酶 (iNOS) 加剧了阿尔茨海默病 (AD) 的病理.
  • 肠道功能障碍与阿尔茨海默病有关,像大肠杆菌这样的细菌诱导iNOS.
  • 开发了一种新的iNOS淘汰赛 (iNOS-KO) 3xTg-AD小鼠模型来研究iNOS的作用.

研究的目的:

  • 研究iNOS-KO对抗AD进展的神经保护潜力.
  • 为了确定iNOS-KO是否可以保持脑血流 (CBF),尽管肠道失调.
  • 评估从轻度认知障碍 (MCI) 患者的便微生物组移植 (FMT) 对INOS-KO/3xTg-AD小鼠的影响.

主要方法:

  • 来自MCI患者和健康对照 (HC) 的便样本用于iNOS-KO/3xTg-AD小鼠的FMT.
  • 在FMT之前,小鼠接受了抗生素治疗.
  • 16S rRNA测序分析了微生物组成;用CASL-EPI进行7TMRI测量了全球CBF.

主要成果:

  • FMT成功地在接受者小鼠中印制了捐赠者的微生物特征,FMT-MCI小鼠显示病原生物的增加.
  • 尽管诱导了肠道失调,但CBF水平在所有组 (FMT-MCI,FMT-HC和对照组) 中都是可比的.
  • 由于iNOS的淘汰,CBF的保存被归因于iNOS.

结论:

  • 与HC相比,MCI患者表现出较高的肠道失调.
  • 在AD模型中,iNOS-KO通过保留CBF来证明其潜在的神经保护作用,即使有失生症.
  • iNOS成为减轻AD风险和病理学的潜在治疗标.