生物标志物 生物标志物
Linda K McEvoy1, Bowei Zhang2, Steve Nguyen2
1Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
通过AgeAccelGrim2测量加速表观遗传衰老,预测与阿尔茨海默病 (AD) 风险相关的大脑缩在女性中大约8年后发生. 这种基于血液的生物标志物还强调了吸烟对大脑健康的负面影响.
科学领域:
- 表观遗传学和衰老的研究
- 神经科学是一个神经科学.
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 表观遗传衰老加速与不良健康结果和死亡率有关.
- 很少有研究前性地研究了与大脑缩相关的表观遗传年龄估计器,特别是在易受阿尔茨海默病 (AD) 影响的地区.
研究的目的:
- 为了检查七种表观遗传年龄估计器与AD的神经解剖风险之间的关联.
- 确定表观遗传衰老加速是否预测AD易受影响的大脑区域的灰质缩.
主要方法:
- 利用了女性健康倡议记忆研究中的1196名女性的数据,评估了表观遗传年龄和AD模式相似性 (AD-PS) 评分,这是灰质缩的衡量标准.
- 采用多重线性回归,根据各种健康和人口因素进行调整,以分析表观遗传年龄估计和AD-PS得分之间的关系.
- 通过APOE ε4状态评估潜在效果修改.
主要成果:
- 两个表观遗传年龄估计器,AgeAccelGrim2和EEAA,与较高的AD-PS得分有显著的关联,表明较大的年龄加速与缩的增加相关.
- 在AgeAccelGrim2内的吸烟包年DNA甲基化替代品与AD-PS得分有积极的关联.
- 在已识别的表观遗传年龄估计和APOE ε4状态之间没有发现相互作用.
结论:
- AgeAccelGrim2,一种血源表观遗传测量方法,可以预测在认知健康的女性中,阿尔茨海默病易受影响的大脑区域的缩,提前8年.
- 这些发现表明,AgeAccelGrim2可能作为AD风险的早期生物标志物.
- 这项研究加强了吸烟在老化过程中对大脑健康的有害影响.
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