痴呆症护理研究和心理社会因素
Shuai Liu1,2, Junyi Wang1,2, Yong Ji1,2
1Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and neurodegenerative diseases, Tianjin dementia institute, Tianjin, Tianjin, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
音乐疗法显著改善了认知功能,并在早期阿尔茨海默病 (AD) 中减少了行为症状. 这种非药物治疗方法也减轻了护理人员的负担,显示出作为AD补充治疗的前景.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 的管理往往寻求非药物干预措施.
- 音乐治疗正在探索其在阿尔茨海默病中的潜在益处,但生物标志物机制需要进一步研究.
- 关于音乐治疗对认知功能,行为症状,日常生活活动和早期老年痴呆症护理人员负担的影响的证据有限.
研究的目的:
- 研究音乐治疗对认知功能,痴呆症的行为和心理症状 (BPSD),日常生活活动 (ADL) 和早期AD的照顾者负担的影响.
- 探索与AD早期音乐治疗干预相关的血生物标志物的潜在变化.
- 评估音乐治疗作为阿尔茨海默氏症早期阶段补充治疗的疗效.
主要方法:
- 一项随机对照试验,涉及61名因AD或轻度AD而出现轻度认知障碍的参与者,通过PET扫描确认β-粉样蛋白.
- 神经心理评估 (MMSE,ADL,NPI,CDR,ZBI) 和血生物标志物 (Aβ1-42,Aβ1-40,pTau181,GFAP,NfL) 在基线和干预后被测量.
- 一般化的线性混合模型被用来分析认知和神经心理学的变化作为主要结果.
主要成果:
- 与对照组相比,音乐治疗干预导致MMSE,NPI和ADL得分在3个月和6个月后显著改善.
- 在6个月后,ZBI分数的显著改善被观察到.
- 在时间定向,回忆 (MMSE) 和激动,冷漠,异常运动行为和夜间干扰 (NPI) 的减少方面注意到了具体的改善.
- 没有发现血生物标志物的统计学意义上的变化,尽管趋势表明APOE ε4载体的ptau181下降.
结论:
- 音乐治疗是一种有效的干预措施,可以改善神经心理症状,并减少早期AD的护理人员负担.
- 虽然血生物标志物变化在统计学上并不显著,但观察到的趋势需要进一步调查.
- 建议音乐治疗作为早期阿尔茨海默病患者有益的补充治疗.
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