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临床表现 临床表现

Gregory L Wallace1, Goldie A McQuaid2, Sean C Duane3

  • 1The George Washington University, Washington D.C., DC, USA.

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自闭症成年人表现出认知能力下降的风险增加,通常与高抗胆固醇药物使用有关. 这项研究强调了在自闭症患者中需要谨慎的药物管理,以减轻痴呆症风险.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 自闭症研究 自闭症研究

背景情况:

  • 医疗保健索赔数据表明,自闭症成年人的痴呆相关诊断率更高.
  • 对自闭症成年人认知衰退风险和痴呆症查器的前性数据缺乏.
  • 自闭症成年人的高多药性可能会导致显著的抗胆固醇负担,这是已知的痴呆风险因素.

研究的目的:

  • 用痴呆症查器评估自闭症成年人的认知衰退风险.
  • 为了记录自闭症成年人的抗胆固醇药物负担.
  • 调查自闭症成年人认知衰退和抗胆固醇负担之间的关联.

主要方法:

  • 通过SPARK招募了两个自闭症成年人的样本:210名"独立" (42-81岁) 和500名"依赖" (18-68岁).
  • 在独立成年人中,认知能力下降被评估为AD8 (自我评级),在依赖成年人中使用DSQIID (照顾者评级).
  • 抗胆固醇药物使用量化使用克里德科抗胆固醇负载量表 (CALS).

主要成果:

  • 30%的独立自闭症成年人和10-3%的依赖自闭症成年人对认知衰退的查结果呈阳性.
  • 两个样本中的63%以上的参与者使用了至少一种抗胆固醇药物.
  • 在这两种样本中,更高的抗胆能效与认知衰退评级的增加显著相关 (p < .01).

结论:

  • 痴呆症查人员证实了自闭症成年人认知能力下降的常见报告,与索赔数据保持一致.
  • 自闭症成年人使用抗胆固醇药物的比例很高.
  • 抗胆固醇活性增加与自闭症成年人的认知衰退报告有关,可能比一般人群年龄更小.