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临床表现 临床表现

Brooke Molina1, Douglas Teixeira Leffa1, Ann D Cohen2,3

  • 1University of Pittsburgh, Pittsburgh, PA, USA.

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概括
此摘要是机器生成的。

注意缺陷多动性障碍 (ADHD) 与阿尔茨海默病 (AD) 风险增加有关. 这项研究评估了中年成人患有多动症的认知功能和AD生物标志物,调查潜在的联系和评估的可行性.

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科学领域:

  • 神经发育障碍 神经发育障碍
  • 神经退行性疾病的神经退行性疾病
  • 老龄化和认知能力

背景情况:

  • 注意缺陷多动性障碍 (ADHD) 持续到成年期,增加轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的风险.
  • 对ADHD的遗传倾向与认知衰退和AD病理生理学有关.
  • 目前的AD研究往往排除了神经发育差异的个体,限制了这些人群对AD途径的理解.

研究的目的:

  • 调查严格诊断的多动症和与年龄相关的疾病 (如AD) 之间的联系.
  • 为了评估认知和AD生物标志物测量的可行性在中年成人与ADHD.
  • 收集有关有多动症史的人的认知功能和AD生物标志物的初步数据.

主要方法:

  • 在匹兹堡ADHD长度研究 (PALS) 的100名参与者中进行认知和AD生物标志物评估.
  • 参与者是中年成年人,儿童时被诊断患有多动症.
  • 这些措施包括认知测试 (MoCA,雷听力语言学习测试) 和基于血液的AD生物标志物 (血Ab42/40,变异体,炎症标志物).

主要成果:

  • 将报告认知功能和AD生物标志物的初步组比较.
  • 由于中期研究进展,将强调效应大小.
  • 将证明中年成人有ADHD病史的评估的可行性.

结论:

  • 了解ADHD与AD的关联是非常重要的,因为成年ADHD患病率不断上升.
  • 这项研究解决了研究ADHD成人的ADD风险的需要.
  • 在这个人群中测量认知和AD生物标志物的可行性正在确定.