临床表现 临床表现
Brooke Molina1, Douglas Teixeira Leffa1, Ann D Cohen2,3
1University of Pittsburgh, Pittsburgh, PA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
注意缺陷多动性障碍 (ADHD) 与阿尔茨海默病 (AD) 风险增加有关. 这项研究评估了中年成人患有多动症的认知功能和AD生物标志物,调查潜在的联系和评估的可行性.
科学领域:
- 神经发育障碍 神经发育障碍
- 神经退行性疾病的神经退行性疾病
- 老龄化和认知能力
背景情况:
- 注意缺陷多动性障碍 (ADHD) 持续到成年期,增加轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的风险.
- 对ADHD的遗传倾向与认知衰退和AD病理生理学有关.
- 目前的AD研究往往排除了神经发育差异的个体,限制了这些人群对AD途径的理解.
研究的目的:
- 调查严格诊断的多动症和与年龄相关的疾病 (如AD) 之间的联系.
- 为了评估认知和AD生物标志物测量的可行性在中年成人与ADHD.
- 收集有关有多动症史的人的认知功能和AD生物标志物的初步数据.
主要方法:
- 在匹兹堡ADHD长度研究 (PALS) 的100名参与者中进行认知和AD生物标志物评估.
- 参与者是中年成年人,儿童时被诊断患有多动症.
- 这些措施包括认知测试 (MoCA,雷听力语言学习测试) 和基于血液的AD生物标志物 (血Ab42/40,变异体,炎症标志物).
主要成果:
- 将报告认知功能和AD生物标志物的初步组比较.
- 由于中期研究进展,将强调效应大小.
- 将证明中年成人有ADHD病史的评估的可行性.
结论:
- 了解ADHD与AD的关联是非常重要的,因为成年ADHD患病率不断上升.
- 这项研究解决了研究ADHD成人的ADD风险的需要.
- 在这个人群中测量认知和AD生物标志物的可行性正在确定.
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