痴呆症护理研究和心理社会因素
Sarah Horn1, Chen-Pin Wang2, Pablo Coss1
1University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
实用试验有效地治疗勒维体疾病 (LBD) 中的精神病,改善招募和多样性. 这种方法提高了西班牙裔人口在帕金森病 (PD) 和患有勒维体 (DLB) 痴呆症研究中的代表性.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 心理药理学 心理药理学
背景情况:
- 奎蒂亚平和皮马万塞林是常见的治疗方式,用于治疗莱维体疾病 (LBD) 中的精神病,包括帕金森病 (PD) 和莱维体痴呆症 (DLB).
- 传统的临床试验在招募,保留和多样性方面面临挑战,特别是在PD神经精神病症状研究中,对于西班牙裔人口来说.
- 现有的试验模型可能无法完全捕捉临床实践中观察到的现实治疗益处.
研究的目的:
- 评估实用性,随机临床试验对LBD精神病的可行性.
- 为了在现实临床环境中比较quetiapine与pimavanserin的疗效.
- 增加少数群体在LBD临床研究中的代表性.
主要方法:
- 一个由调查者发起的,局部的,务实的,随机的,未盲目的试验,比较西和皮马万塞林治疗LBD精神病.
- 通过随机选择药物选择,在常规护理中进行管理,访问与临床预约相结合.
- 主要结局:从基线到6个月的NPI-Q幻觉/错觉得分的变化;次要结局包括NPI-Q总得分,总体变化印象,不良事件和成本.
主要成果:
- 49名参与者 (83.7%的PD,16.3%的DLB) 注册; 40.8%的人被认定为西班牙裔,反映了当地人口.
- 保持率高,只有2名参与者失去了随访 (1人死亡,1人退出).
- 该试验成功招募了多样化的受试者,其中包括很大比例的西班牙裔受试者.
结论:
- 实用性临床试验对于研究LBD患者的精神病是可行的和有效的.
- 这种试验模型解决了传统研究设计中固有的招聘和保留挑战.
- 实用试验提高了少数群体的代表性,使研究人口统计与临床人群保持一致.
更多相关视频
08:36The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
Published on: July 28, 2022
4.3K
10:13Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
14.1K
相关概念视频
01:30Dementia
482
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
482
01:29Psychological and Sociocultural Causes of Schizophrenia
438
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
438
01:26Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
01:22Alzheimer's Disease: Treatment
744
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
744
01:30Cognitive Development During Adulthood
740
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
740
01:29Documentation in Long-Term and Home Healthcare Setting
1.4K
Documentation in long-term care facilities and home healthcare settings is crucial for ensuring continuous, coordinated, and comprehensive care for patients. Each setting has its specific documentation processes and tools:
Long-Term Care Facilities
Long-Term Care Facilities
1.4K