临床表现 临床表现
Narueporn Pagowong1,2,3, Kanokphong Suparan1,2,4, Chanon Kunasol1,2,3
1Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
最近的急性冠状动脉综合征 (ACS) 患者表现出肠道失调和认知能力下降. 特定的肠道细菌,如Peptostreptococcus可能表明ACS幸存者的认知障碍.
科学领域:
- 微生物组研究的研究.
- 心血管医学 心血管医学
- 神经科学是一个神经科学.
背景情况:
- 肠道失调与认知障碍和急性冠状动脉综合征 (ACS) 有关.
- 最近的ACS患者的肠道微生物群和认知功能之间的关系尚不清楚.
研究的目的:
- 研究最近的ACS患者的肠道微生物群组成和认知功能.
- 在ACS患者和高心血管风险控制者之间比较肠道微生物群和认知结果.
主要方法:
- 招募了50名ACS患者和42名高心血管风险对照.
- 使用蒙特利尔认知评估 (MoCA) 评估神经认知功能.
- 通过便样本的16SrRNA测序分析了肠道微生物组合.
主要成果:
- 与对照组相比,ACS患者在所有领域表现出明显较低的MoCA得分和认知功能.
- ACS患者表现出肠道功能失调,微生物多样性和组成发生变化,包括Firmicutes/Bacteroidota和Enterobacteriaceae/Proteobacteria的比率增加.
- 在ACS患者的特定肠道类型 (Peptostreptococcales-Tissierellales,Peptostreptococcus) 和MoCA得分之间发现了负相关性.
结论:
- 肠道微生物群的变化与最近的ACS患者的认知障碍有关.
- 佩普托斯特雷普托科卡莱斯-蒂塞雷拉莱斯和佩普托斯特雷普托科库斯可能成为ACS患者认知障碍的潜在生物标志物.
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