生物标志物 生物标志物
Allison J Huff1, Juyoung Park2, Samuel Montero-Hernandez3
1University of Arizona, Tucson, AZ, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
功能近红外光谱学 (fNIRS) 可以识别阿尔茨海默病和相关痴呆症 (ADRD) 中的冷漠和疼痛的生物标志物. 大脑活动模式根据认知功能不同,有助于量身定制的干预.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 老年学是指老年学的学科.
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 呈现出渐进的神经退行.
- 慢性疼痛和神经精神症状在ADRD中很常见,可能会加剧认知能力下降.
- 了解疼痛,神经精神症状和大脑活动之间的相互作用对于管理ADRD至关重要.
研究的目的:
- 研究ADRD患者自我报告的疼痛,神经精神症状和皮质血液动力学变化之间的关系.
- 探索认知功能 (高与低) 如何影响这些关系.
- 评估功能近红外光谱学 (fNIRS) 在描述这些关联方面的实用性.
主要方法:
- 功能近红外光谱 (fNIRS) 测量了40名患有ADRD和慢性疼痛的参与者的前额叶和运动皮层的脑血动力变化.
- 用验证的问卷来评估自我报告的疼痛,抑郁和冷漠.
- 根据认知评估得分,参与者被分为高认知功能和低认知功能组.
主要成果:
- 在具有低认知功能 (p=0.04) 的个体中,在右额头区域观察到氧血球和冷漠之间的显著负相关性.
- 在具有高认知功能的人群中,在右运动区域发现了氧血球和冷漠之间的显著正相关性 (p=0.04).
- 在具有较高认知功能 (p=0.04) 的个体中,在中额头区域观察到氧血球和疼痛之间的正相关性.
结论:
- fNIRS在ADRD中显示出作为冷漠和抑郁症的生物标志物的潜力.
- 与神经精神症状相关的大脑活动的不同模式表明基于认知状态的不同表现.
- 这些发现可能会为ADRD患者的神经精神症状提供更有效,更个性化的干预措施.
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