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Updated: Jan 7, 2026

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葡萄糖诱导DNMT1/IMPDH2-依赖的代谢记忆在内皮细胞在重编程核酸代谢后

Sampara Vasishta1, Ganesha Poojary1,2, Sarmeela Sharma3

  • 1Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|December 25, 2025
PubMed
概括

2型糖尿病代谢记忆涉及表观遗传变化,DNMT1和IMPDH2通过改变核酸代谢和细胞功能,甚至在葡萄糖正常化后,也会导致糖尿病视网膜病变等血管并发症.

关键词:
通过DNA甲基化.它们的内皮质 (endothelium).外基因组是外基因组的组成部分.代谢记忆的代谢记忆核酸代谢的核酸代谢视网膜病变是一种视网膜病变.

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