临床表现 临床表现
Elizabeth Riley1, Genevieve Wager1, Eve De Rosa1
1Cornell University, Ithaca, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在年轻和年长的成年人中,通过皮肤进行的耳道迷走神经刺激 (taVNS) 对瞳孔的反应有不同的影响. 年长的成年人显示,瞳孔反应显著下降,这表明与年龄相关的部功能差异.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 医疗器械 医疗器械
背景情况:
- 脑位 (LC) 对于认知功能至关重要,也是阿尔茨海默病中神经退行早期的部位.
- 通过穿皮耳迷走神经刺激 (taVNS) 调节LC活动可能会影响北上腺素的释放和疾病的进展.
- 随着寿命的推移,LC的结构和功能会有所不同,因此需要对taVNS效应进行特定年龄的研究.
研究的目的:
- 研究taVNS对年轻人与老年人的瞳孔反应的差异影响.
- 探讨通过taVNS.调节的脑位 (LC) 功能中与年龄相关的差异.
主要方法:
- 21名参与者 (12名年轻人,9名年长者) 在一次视觉奇怪任务中接受了假和真实taVNS,同时进行瞳孔测量.
- 使用了个性化的taVNS参数 (25 Hz,250 μs脉冲宽度).
- 通过使用更明亮的标准刺激来控制瞳孔光反射.
主要成果:
- 观察到taVNS治疗对瞳孔对奇怪刺激的反应有显著的影响 (p=0.009).
- 在年龄组和taVNS治疗之间发现了显著的相互作用 (p=0.0007).
- 年轻的成年人与verum taVNS显示出无意义的瞳孔反应增加,而老年人显示出显著下降 (30.5%,p=0.0002).
结论:
- 在年轻人和老年人中,taVNS对瞳孔反应产生不同的影响.
- 这些研究结果表明,与年龄相关的部 (locus coeruleus,LC) 功能发生变化.
- 这项试点研究强调了对神经疾病taVNS应用中的特定年龄考虑的必要性.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


