药物开发 药物开发
Girdhari Lal Gupta1, Nikita Patil2
1SVKM'S NMIMS University, Shirpur, Dhule, Maharashtra, India.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
通过减少炎症和氧化应激,avicularin治疗改善了遭受慢性压力的小鼠的认知功能. 这种天然化合物在治疗与压力相关的认知衰退方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性不可预测的压力 (CUS) 通过 kynurenine (KYN) 途径模型认知障碍和神经退行.
- 压力会增加皮质醇,激活微质细胞,增加林酸 (QA),减少来自大脑的神经营养因子 (BDNF),导致神经退行.
- 以抗氧化剂和抗抑郁剂作用而闻名的阿维库拉林被调查用于对CUS诱导的认知缺陷进行神经保护.
研究的目的:
- 在小鼠模型中评估avicularin对CUS诱导的认知障碍的神经保护潜力.
- 评估avicularin对压力生物标志物,神经炎症,氧化应激和认知表现的影响.
主要方法:
- 小鼠接受了五周的CUS治疗,在最后几周接受了飞鸟素 (50,100,200毫克/公斤).
- 行为测试 (强迫游泳,糖偏好,莫里斯水迷宫,被动回避) 评估认知功能.
- 生物化学分析测量了皮质类固醇,氧化应激,神经递质 (血清素,上腺素),炎症性细胞因子 (TNF-α,IL-6,IL-1β),乙胆酶 (AChE),BDNF和β-氨酸.
主要成果:
- 阿维林显著提高了认知表现,降低了皮质水平和氧化应激.
- 100和200毫克/千克的飞鸟素剂量增加了血清素,上腺素和BDNF水平.
- 治疗导致粉样β,炎症性细胞因子和ACHE活性下降.
结论:
- 阿维库林对CUS诱导的认知障碍具有显著的神经保护作用.
- 它有效地减少神经炎症并增强神经营养支持.
- 阿维林具有作为治疗应激相关认知功能障碍的治疗剂的潜力.
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