生物标志物 生物标志物
Pierfilippo De Sanctis1, Theo Vanneau1, Wenzhu B Mowrey1
1Albert Einstein College of Medicine, Bronx, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
早期的认知障碍 (CI) 与双重任务行走期间不同的大脑活动模式有关. 这项研究使用EEG和运动跟踪来识别老年人功能衰退的神经标记,有助于早期发现痴呆症.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 日常活动的功能性下降是痴呆症综合征的标志.
- 微妙的限制在轻度认知障碍 (MCI) 诊断之前.
- 与早期痴呆症相关的功能衰退的神经支是鲜为人知的.
研究的目的:
- 调查不同认知障碍 (CI) 风险的老年人功能衰退的神经相关性.
- 使用双重任务行走模式与脑电图 (EEG) 和3D身体跟踪.
- 在复杂的任务中确定与较高的CI风险相关的独特的大脑激活模式.
主要方法:
- 招募了36名65岁以上的个人,分为低风险 (蒙特利尔认知评估[MoCA] ≥27) 和高风险 (MoCA ≤26) 组.
- 采用了一种与便携式EEG和3D身体跟踪同步的双重任务行走范式.
- 分析了与步态相关的大脑活动:8-28Hz在前/后中心回环 (感官运动) 上,3-7Hz在前中皮层 (运动控制) 上.
主要成果:
- 较高的CI风险与双重任务行走期间的表现较差有关.
- 在高风险组中观察到明显的前额-双脑大脑激活模式.
- 在传感器和运动控制区域的特定EEG频段区分了风险组.
结论:
- 结合EEG和3D运动跟踪方法提供高时空分辨率,用于分析复杂的日常功能期间的大脑活动.
- 这种方法提供了具体任务,大脑区域和频谱洞察早期功能衰退.
- 这种方法有可能改善预测和识别早期痴呆干预的非侵入性脑刺激目标.
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