生物标志物 生物标志物
Yingqi Liao1, Cheuk Ni Kan1, Shi Yu Chan2
1Memory, Ageing, and Cognition Centre (MACC), Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
轻度行为障碍 (MBI) 与海马体和默认模式网络 (DMN) 之间的连接性降低有关. 脑血管疾病和神经炎症可能会恶化这种关系,增加痴呆风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 轻度行为障碍 (MBI) 是痴呆风险增加的早期指标.
- 人们还没有完全理解MBI的潜在机制.
- 在MBI中观察到皮层网络中的功能连接 (FC) 发生变化.
研究的目的:
- 为了研究MBI的皮质-亚皮质FC相关物.
- 检查MBI,阿尔茨海默病生物标志物和脑血管疾病生物标志物之间的关系.
主要方法:
- 238名没有痴呆症的参与者接受了神经心理测试和休息状态功能性MRI.
- 在皮下边缘区域和皮层网络 (DMN,FPCN,SN) 之间分析了休息状态功能连接 (RSFC).
- 回归模型检查了MBI和RSFC之间的关联,以及它们与白质超强度体积 (WMHV),p-Tau181和GFAP的相互作用.
主要成果:
- 减少左海马-DMN RSFC与更高的全球MBI得分有关,特别是动机和情感失调.
- 白质高强度体积 (WMHV) 和状纤维酸蛋白 (GFAP) 显著缓解了左海马-DMN RSFC 和MBI之间的关联.
- 这种关联仅对高WMHV或高GFAP具有意义,这表明大脑血管病理和神经炎症的作用.
结论:
- 在DMN的皮层-亚皮层功能性改变与MBI有关.
- 脑血管病理和神经炎症可能会调节MBI中的大脑行为关系.
- 需要进一步的研究来探索这些调节痴呆风险的调节因素.
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