生物标志物 生物标志物
Lindsey A Kuchenbecker1, Kevin J Thompson2, Cheyenne D Hurst1
1Mayo Clinic, Jacksonville, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
研究人员发现了36种血蛋白,可以在非洲裔美国人中准确诊断阿尔茨海默病 (AD). 这种新的生物标志物小组显示出高准确性和在不同人群中改善AD诊断的潜力.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 蛋白质组学是指蛋白质组学.
背景情况:
- 血生物标志物提供了可访问的阿尔茨海默病 (AD) 诊断.
- 目前的候选人缺乏在不同人群中验证,并错过了关键的AD途径.
- 非洲裔美国人 (AA) 患痴呆风险较高,但在AD研究中代表性不足.
研究的目的:
- 在非洲裔美国人 (AA) 中发现AD的新型血生物标志物.
- 确定一个蛋白质面板,以区分AD痴呆症和认知障碍.
- 在不同的人口中验证生物标志物的普遍性.
主要方法:
- 在AA参与者的血中未针对性蛋白质组 (SomaScan 7k) (AD痴呆症n=181,CUn=142).
- 机器学习 (弹性净回归) 来识别预测性蛋白质.
- 在混合队列中进行外部验证 (NHW和AA,n=369).
主要成果:
- 三十六种蛋白质被确定为AD痴呆症的预测因素.
- 与AD途径相关的选定蛋白质:突触功能障碍,炎症,血管问题.
- 36个蛋白质小组实现了AUC=0.94,在发现和验证队列中,年龄/性别模型的表现优于22-35%.
结论:
- 非定位蛋白质组学和机器学习产生了一种新的,准确的AD血生物标记面板.
- 这个小组显示了改善AD诊断的希望,特别是在代表性不足的群体中.
- 未来的工作将将面板与p-tau217,并发症和健康的社会决定因素联系起来.
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