生物标志物 生物标志物
Jian Xiang Ding1, Oneil G Bhalala1,2, Kai Sin Chin1,2
1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在临床环境中,招募痴呆症血液生物标志物研究是可行的. 务实的设计和最小的排斥成功地招募了各种各样的参与者,包括老年人和来自不同文化背景的人.
科学领域:
- 神经学 神经学
- 生物标志物研究 生物标志物研究
- 临床试验 临床试验
背景情况:
- 为痴呆症临床研究招募患者面临挑战,特别是在老年人群和文化和语言多样性 (CALD) 的人群中.
- 这项研究通过在公共医院记忆诊所建立血液生物标志物队列来解决这些挑战.
研究的目的:
- 描述正在进行的血液生物标志物队列研究的建立和早期招募经验.
- 评估招募各种患者群体用于痴呆症研究的可行性.
主要方法:
- 从2023年10月起,招聘发生在皇家墨尔本医院的认知,痴呆和记忆服务 (CDAMS) 诊所.
- 使用了广泛的纳入标准,包括那些需要口译员或决策者的人,以及为期12个月的远程医疗随访.
- 采集了血液样本,以分析血神经丝光链和-tau-217.
主要成果:
- 在200名参与者中,招募了73名,同意率为90%.
- 该队伍的平均年龄为78岁,其中63%是女性.
- 21%的参与者来自CALD背景.
结论:
- 痴呆症血液生物标志物研究在临床环境中使用实用设计是可行的.
- 尽量减少排斥标准和访问负担,有助于招募多样化,临床相关的人群.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516