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临床表现 临床表现

Manuela Tondelli1, Daniela Ballotta1, Riccardo Maramotti1,2,3

  • 1Università di Modena e Reggio Emilia, Modena, Italy.

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概括
此摘要是机器生成的。

阿尔茨海默病的意识与大脑网络功能有关. 超意识的个体表现出改变的默认模式网络连接,而无意识的个体表现出突出和前端平行网络的变化.

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科学领域:

  • 神经科学是一个神经科学.
  • 认知科学 认知科学

背景情况:

  • 阿尔茨海默病 (AD) 中的无意识与默认模式 (DMN), Salience (SN) 和前端-平行 (FPN) 网络中的失调有关.
  • 调查这种功能连接失调的轨迹在整个意识谱 (超级认知到无意识) 中至关重要.

研究的目的:

  • 检查DMN,SN和FPN中的功能连接在轻度认知障碍和AD痴呆症患者的不同意识水平中如何不同.
  • 为了确定特定的网络连接模式是否与超意识,正常意识或无意识相关.

主要方法:

  • 60名患有轻度认知障碍 (MCI) 和AD痴呆症的患者接受了功能性MRI (fMRI) 和神经心理测试.
  • 参与者被分为超意识 (hyAW),无意识 (uAW) 和意识 (AW) 组,这些组的分类是基于无意识痴呆症问卷 (AQ-D) 的差异得分.
  • 用独立组件分析 (ICA) 分析了静止状态fMRI数据,以评估DMN,SN和FPN内的功能连接性.

主要成果:

  • 过度警觉 (hyAW) 的受试者在后侧环状皮质和中环状皮质中显示出增加的DMN连接性.
  • 无意识 (uAW) 试验对象在前带状皮质,前胰岛和基底质中表现出较高的SN连接性,与有意识的组相比.
  • 无意识 (uAW) 试验对象与超意识的试验对象相比,还在下额头回环中表现出增强的FPN连接.

结论:

  • 阿尔茨海默病的意识水平与DMN,SN和FPN中不同的功能连接模式有关.
  • 网络招聘遵循意识谱的渐变,为AD的意识缺陷的神经基础提供了洞察力.