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微针药物治疗肥胖的进展:机制,应用和前景

Chengyu Wu¹, Ziliang Zong², Feiran Hua²

¹Department of General Surgery, The Affiliated Wuxi No. 2 Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002, People's Republic of China.

International journal of nanomedicine

|December 25, 2025

概括

微针 (MN) 贴片提供了一种最小侵入性的方法来提供肥胖治疗,绕过消化并准脂肪组织. 在扩大生产规模和确保广泛临床使用一致的皮肤透方面仍然存在挑战.

科学领域:

生物医学工程生物医学工程
药理学药理学是指药理学的学科.
代谢障碍代谢障碍代谢障碍

背景情况:

肥胖是一种复杂的代谢障碍,与糖尿病和心血管疾病等严重的健康风险有关.
目前的肥胖治疗面临的挑战包括患者不良坚持,副作用和低效的药物输送.
使用微针 (MNs) 通过皮肤输送药物提供了一种最小侵入性和患者友好的替代方案.

研究的目的:

探索基于微针 (MN) 的透皮系统在治疗肥胖症方面的潜力.
审查MNs在向脂肪组织输送各种治疗剂方面的优势.
确定目前的挑战和未来的方向在肥胖管理中使用MN技术.

主要方法:

对基于MN的超皮药物供应用于肥胖症的最新研究的综述.
分析不同的MN设计 (溶解,水凝形成,刺激反应) 和它们的释放动力学.
通过MN传递的治疗剂的评估,包括小分子,,核酸和纳米粒子.

主要成果:

MN平台绕过胃肠道降解和肝脏第一通代谢,使向脂肪组织的向输送成为可能.
脑膜炎可以提供多种不同的药物来调节脂肪代谢,减少炎症,并促进棕色脂肪组织 (BAT) 色.
各种MN设计提供可控的药物释放,从快速到持续的输送.

结论:

微针技术显示出一种新的,以患者为中心的肥胖治疗方法的重大前景.
关键的挑战包括药物载荷能力,皮肤透的可变性,局部反应和可扩展的GMP制造.
未来的进步可能涉及纳米载体,人工智能驱动的设计,以及用于个性化,适应性肥胖治疗的可穿戴设备.

关键词:

脂肪组织的新陈代谢微针微针是一种微针.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖通过皮肤传递药物.

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