来自段落回忆的语言特征是认知障碍的标记
Seho Park1, Nicole Roth1, Megan Barker2,3
1Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.
medRxiv : the preprint server for health sciences
|December 25, 2025
概括
在回忆测试中分析语言可以检测认知障碍. 对段落回忆 (PFS) 的语言分析显示了识别认知衰退和帮助自动评估的前景.
科学领域:
- 神经心理学 神经心理学
- 语言学的语言学.
- 老年学是一门学科.
背景情况:
- 认知障碍与细微的语言变化有关,传统的评分方法并不总能捕捉到这些变化.
- 神经心理评估中的口头反应为识别认知状态提供了丰富的数据.
研究的目的:
- 评价语文分析的有效性段落回忆区分有和没有认知障碍的个人.
- 探索语言多特征评分 (PFS) 在预测认知衰退方面的实用性.
主要方法:
- 分析了长寿家庭研究中710名参与者的数字语音录音 (598名正常认知,112名认知障碍).
- 立即 (PFS-IR) 和延迟回忆 (PFS-DR) 的语言多特征得分被计算出来.
- 使用后勤回归和重复测量模型来评估PFS对认知状态和下降的预测值.
主要成果:
- 无论是PFS-IR还是PFS-DR都与认知状态有显著的关联.
- 使用PFS-DR和人口统计数据的分类器显示准确度与传统的逻辑记忆得分相当.
- 较高的PFS-DR预测了在5年的随访期内更大的认知衰退.
结论:
- 通过PFS量化语言特征可以有效地检测认知障碍,并预测未来的认知衰退.
- 语言PFS可以集成到自动化管道中,用于更广泛的临床和研究应用.
- 这种方法提高了神经心理学评估的敏感性.
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