在艾滋病毒感染者中,抑郁症与发生的I型MI有关
medRxiv : the preprint server for health sciences
|December 25, 2025
概括
被诊断为抑郁症增加了艾滋病毒 (PWH) 感染者的1型心肌梗塞 (T1MI) 风险. 在这个人群中,焦虑与T1MI或T2MI没有显著的关联,这突显了心理健康在PWH心血管护理中的重要性.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 抑郁和焦虑与一般和艾滋病毒阳性人群中心肌梗塞 (MI) 风险较高有关.
- 关于精神健康状况与特定的肌肉梗塞类型 (1型与1型相比) 之间的关联的研究有限. 2型) 在艾滋病毒感染者 (PWH) 中.
研究的目的:
- 调查诊断出抑郁症和/或焦虑症与艾滋病毒感染者 (PWH) 中1型心脏病发作 (T1MI) 或2型心脏病发作 (T2MI) 的发生率之间的关系.
主要方法:
- 利用了来自七个NA-ACCORD临床队列 (1997-2019) 的数据,判断了第一个心脏病发作事件.
- 定义的抑郁或焦虑使用时间变化的ICD-9/10代码在MI之前.
- 使用Cox的比例危险模型来分析关联,调整人口统计和MI风险因素.
主要成果:
- 抑郁症与T1MI风险增加显著相关 (aHR,1.22 [95% CI,1.00-1.48]).
- 焦虑与T1MI (aHR,0.86 [95% CI,0.70-1.07]) 的保护性关联不显著.
- 无论是抑郁还是焦虑都没有显示出与T2MI具有统计学意义的关联.
结论:
- 在艾滋病毒感染者 (PWH) 中,被诊断出抑郁症与T1MI有关,但与T2MI无关.
- 焦虑没有显示出与任何一种MI类型的统计学上显著的关联.
- 心理健康评估和管理对于PWH的心血管健康至关重要.
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