较慢的反应性步进动力学与较低的临床平衡功能和在中风后具有挑战性的平衡条件下延迟皮质唤起的反应有关
Si-Yu Tsai1, Aiden M Payne2, Jasmine L Mirdamadi3
1Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, University of Minnesota Medical School, USA.
medRxiv : the preprint server for health sciences
|December 25, 2025
概括
脑卒中后的人推迟了反应性步行,影响了跌倒预防. 皮层处理速度较慢,而不是承重不对称,导致中风后平衡控制受损.
科学领域:
- 神经科学是一个神经科学.
- 生物力学 生物力学
- 康复科学 康复科学 康复科学
背景情况:
- 预防跌倒依赖于迅速恢复平衡.
- 脑卒中后的个体表现出受损的反应性步进动力学.
- 脑卒中后渐进性缺陷的神经相关性尚未得到充分理解.
研究的目的:
- 在个性化扰动大小下调查中风幸存者的步进动力学.
- 检查神经机械和神经机制,是中风后脚步障碍的基础.
主要方法:
- 16名中风幸存者和16名对照者经历了个性化的平衡扰乱.
- 量化时空步进动力学和动前的负载重量不对称.
- 测量皮层N1反应 (100-300ms) 作为平衡控制的神经相关物.
主要成果:
- 卒中幸存者表现出延迟的步骤启动和终止延迟.
- 延迟步骤启动与较差的临床平衡和较慢的皮质反应相关.
- 在小组层面上,没有观察到步骤持续时间,速度或轨迹的显著差异.
结论:
- 皮层处理速度可能会在中风后限制平衡功能.
- 延迟的反应步骤与皮质处理受损有关.
- 在中风康复中,确定了用于跌倒预防策略的神经机械目标.
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