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作为T型淋巴细胞淋巴瘤的初始表现,急性功能衰竭:一个病例报告

Noureldien Darwish¹, Andrea Lightle¹

¹Department of Pathology and Laboratory Medicine, Albany Medical College, Albany NY, USA.

Clinical nephrology. Case studies

|December 25, 2025

概括

罕见地,T-淋巴细胞淋巴瘤/白血病 (T-LBL) 可能伴有功能衰竭. 这一案例凸显了活检对于诊断T-LBL的重要性,即使没有典型的血液异常.

科学领域:

血液学血液学血液学
在瘤学瘤学.
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

型淋巴细胞淋巴瘤/白血病 (T-LBL) 是一种具有攻击性的血液性恶性瘤.
在T-LBL中,初级脏参与是罕见的,并且在诊断上具有挑战性.
急性功能衰竭可能是T-LBL的初始表现.

研究的目的:

呈现一种罕见的T-LBL病例,主要表现为参与和急性功能衰竭.
为了强调脏活检在无法解释的功能衰竭的诊断效用.
突出考虑T-LBL在间歇性炎差异诊断中的重要性.

主要方法:

一个11岁的男性患有新发作,高血压危机和急性功能衰竭的病例报告.
诊断工作包括脏超声波,脏活检,骨髓活检,PET/CT和MRI.
用免疫组织化学和流动细胞计量来描述T细胞透的特征.

主要成果:

最初的脏活检显示了非典型的T细胞透,表明T细胞急性淋巴细胞淋巴瘤/白血病 (T-ALL/LBL).
随后的调查证实了IV期T-LBL,包括脏,胰腺,上腺和肝脏在内的广泛的器官参与.
骨髓和周围血液显示白血病的证据很少或不存在.

结论:

在T-LBL中,由于白血病透导致的功能衰竭并不常见,但有可能发生.
脏活检对于诊断T-LBL出现功能衰竭至关重要,特别是当血液学发现异常时.
淋巴瘤应考虑在隔膜性炎的差异诊断中,无论外周血液的发现如何.

关键词:

在T细胞淋巴细胞白血病/淋巴瘤.急性功能衰竭急性功能衰竭过高血压危机的危机质量质量质量

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