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在直肠瘤短期放射治疗期间明显扩散系数增加:来自多中心纵向试验的结果

Anne L H Bisgaard¹, Chavelli M Kensen², Marielle E P Philippens³

¹Laboratory of Radiation Physics, Odense University Hospital, Odense, Kløvervænget 19, 5000 Odense, Denmark.

Physics and imaging in radiation oncology

|December 25, 2025

概括

在短疗程放射治疗期间明显扩散系数 (ADC) 变化在56%的直肠癌患者中可检测到. 这支持使用基于MRI-linac的扩散权重成像 (DWI) 进行治疗个性化的多中心研究.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
医疗成像医学成像

背景情况:

从扩散加权成像 (DWI) 获得的明显扩散系数 (ADC) 在预测长期接受新辅助化疗或放射治疗的直肠癌的治疗反应方面表现有希望.
这项研究探讨了直肠癌短期放射治疗 (SCRT) 期间的ADC变化.

研究的目的:

调查直肠癌患者在短疗程放射治疗 (SCRT) 期间明显扩散系数 (ADC) 变化的检测能力.
评估使用MRI-linac基于DWI的多中心调查的可行性.

主要方法:

138名直肠癌患者在1.5TMRI-linac.ly上接受了SCRT (5x5 Gy) 的治疗.
在每个分数期间获得扩散权重成像 (DWI),ADC地图以中心计算.
分析了ADC的时间趋势,用于信任区间的线性拟合和启动.

主要成果:

在SCRT期间,56%的患者可以检测到明显扩散系数 (ADC) 变化.
ADC时间趋势的中位斜率为0.05 (10^-3 mm^2/s/分数).
斜率的95%置信区间在56%的患者中排除了零.

结论:

在直肠癌的短疗程放射治疗期间可以检测到ADC变化.
跨DWI序列的有限ADC变化支持使用MRI-linac DWI的多中心研究.
这些发现鼓励研究将ADC与个性化直肠癌治疗的临床结果联系起来.

关键词:

表面扩散系数的明显扩散系数扩散权重的MRI测试结果通过MRI-Linac进行核磁共振.辐射疗法辐射疗法这是直肠癌.

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