残留炎症风险与急性缺血性中风后的认知障碍有关
Yuwen Gang1,2, Xiuqun Gong1, Beibei Zhu1
1Department of Neurology, the First Hospital of Anhui University of Science and Technology, Huainan, Anhui Province, People's Republic of China.
Neuropsychiatric disease and treatment
|December 25, 2025
概括
残留炎症风险 (RIR) 与急性缺血性中风 (AIS) 患者的中风后认知障碍 (PSCI) 有关. 这一发现突出了炎症.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 炎症研究 炎症研究
背景情况:
- 急性缺血性中风 (AIS) 可以导致认知障碍.
- 炎症反应显著导致中风后认知障碍 (PSCI).
- 剩余炎症风险 (RIR) 和剩余胆固醇风险 (RCR) 是需要调查的关键因素.
研究的目的:
- 研究急性缺血性中风 (AIS) 患者的残留炎症风险 (RIR) 和中风后认知障碍 (PSCI) 的发展之间的关系.
- 为了确定RIR是否是PSCI的独立预测指标.
主要方法:
- 一项前性队列研究,涉及172名被诊断患有AIS的患者.
- 根据低密度脂蛋白胆固醇 (LDL-C) 和高灵敏性C反应蛋白 (hsCRP) 水平,患者被分为四组:只有RIR,只有RCR,两种风险 (RCIR),没有风险.
- 在中风后6个月,PSCI被定义为蒙特利尔认知评估 (MoCA) 分数低于22分.
- 用多变量后勤回归分析来评估RIR和PSCI之间的关联.
主要成果:
- 在172名患者中,58名 (33.7%) 患有PSCI.
- 与没有PSCI的患者相比,患有PSCI的患者表现出高脂血症,RIR,白细胞计数升高和中性粒细胞计数较高的患病率.
- 多变量后勤回归确定了RIR (OR 4.496,P=0.030) 和RCIR (OR 7.357,P=0.002) 作为与PSCI相关的独立因素.
结论:
- 这项研究提供了第一个证据,将残留炎症风险 (RIR) 与急性缺血性中风患者中中风后认知障碍 (PSCI) 的发生联系起来.
- 在缺血性中风后,RIR是发展认知障碍的重要独立风险因素.
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