神经发育障碍中肠道微生物组合的变化:系统性审查和元分析
Hua Yang1,2, Anqi Wang1,2, Jie Yang1,2
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in microbiology
|December 25, 2025
概括
肠道微生物组的改变与神经发育障碍 (NDD) 有关. 虽然α多样性没有显示任何变化,但β多样性显示了NDD子组中不同的微生物群落,特定的细菌家族和属有显著差异.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 神经发育障碍 (NDD) 越来越多地与肠道微生物组的改变有关.
- 在NDD中这些肠道微生物变化的确切性质和程度仍然不完全理解.
- 这项研究调查了被诊断为NDDs的个体的肠道微生物群多样性和组成的变化.
研究的目的:
- 系统地审查和分析有关NDD肠道微生物群的现有研究.
- 为了比较NDD患者和健康对照之间的微生物多样性 (α和β) 和相对丰度.
- 识别与NDD相关的特定细菌种群.
主要方法:
- 系统的文献搜索进行到2025年4月.
- 使用STATA 16.0进行的元分析以评估α多样性,β多样性和相对丰度.
- 具有NDD和健康对照的个体之间的比较.
主要成果:
- 在NDD和对照组之间没有观察到α多样性的显著差异.
- 贝塔多样性分析表明,在自闭症谱系障碍 (ASD),注意力缺陷/多动症障碍 (ADHD) 和滴答障碍 (TD) 分组中存在不同的微生物群体.
- 增加的Peptostreptococcaceae和Eubacterium,减少的Escherichia/Shigella和Roseburia,在家族和属级的NDD中被注意到.
结论:
- 肠道微生物群的组成在NDD中发生了复杂的变化,在β多样性,家族和属级别上观察到显著差异.
- 结果受到研究异质性和小样本大小的限制.
- 需要进行更大规模的标准化研究,以进一步阐明肠道微生物组与NDD的关联.
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