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Updated: Jan 7, 2026

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错误的分段转录推理纠正用于改进空间转录学分析.

Yuqiu Yang1, Erica DePasquale2,3, David Adeleke2

  • 1Quantitative Biomedical Research Center, Department of Health Data Science and Biostatistics, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA, 75390.

bioRxiv : the preprint server for biology
|December 25, 2025
PubMed
概括

在空间解析的转录组学 (SRT) 数据中,MISTIC 纠正了转录错误分配错误,而无需重新分割. 这改善了细胞类型识别,差异表达和RNA局部化分析,以获得更深入的生物学见解.

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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