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Updated: Jun 13, 2026

Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform
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人类外周血液的单细胞细胞因子字典

Lukas Oesinghaus1,2, Sören Becker3,4, Larsen Vornholz3

  • 1Department of Electrical and Computer Engineering, University of Washington, Seattle, USA.

bioRxiv : the preprint server for biology
|December 25, 2025
PubMed
概括

这项研究引入了人类细胞因子词典,这是一个全面的资源,详细介绍了90种细胞因子如何影响数百万个人类免疫细胞. 它揭示了细胞特异性反应和通信网络,有助于疾病研究和药物发现.

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Regulation of Hematopoietic Stem Cells

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Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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