晶胺蛋白的细胞内聚合受到Hsp70陪伴者的限制

Claire M Radtke1, Adam S Knier1,2, Sean A Martin1

  • 1Department of Biological Sciences, Marquette University, Milwaukee, WI, 53201-1881 USA.

概括

分子陪伴物,特别是Hsp70s,限制了酵母中的细胞内基胺 (TTR) 的聚合. 这表明,随着年龄的增长,蛋白质稳定性下降可能会通过促进细胞内TTR积累来加剧TTR氨基粉症 (ATTR).

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