相关实验视频
Updated: Jan 7, 2026

07:43
Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
22.4K
甲基形成使胃被菌动物 (Fusobacterium animalis) 殖民
C Gómez-Garzón1, Q Chen1, V P O'Brien2
1Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington.
bioRxiv : the preprint server for biology
|December 25, 2025
概括
杆菌感染可以导致胃转化,创造了一个易受Fusobacterium animalis二次殖民的环境,这是一种与胃癌有关的细菌. 这项研究阐明了这种相互作用的机制.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 在全球范围内,Helicobacter pylori感染是胃癌的主要危险因素.
- 杆菌破坏胃微生物组,允许像Fusobacterium物种这样的口腔细菌进行二次殖民,这些细菌与胃肠道癌症有关.
研究的目的:
- 调查菌物种,特别是F. animalis和F. nucleatum在H. pylori相关的胃变化和癌症的作用.
- 了解这些细菌在胃环境中的粘附,入侵和殖民机制.
主要方法:
- 使用培养的人类胃腺癌细胞进行体外研究,以评估细菌粘附和入侵.
- 在体内研究使用胃转化成形的小鼠模型来评估细菌殖民.
- 对细菌与宿主细胞糖蛋白 (GalNAc) 和环境因素 (低氧,胃酸) 的相互作用进行分析.
主要成果:
- F. animalis和F. nucleatum都侵入了胃腺癌细胞,而F. animalis显示出更高的粘附率和入侵率.
- 外源GalNAc抑制了细菌的粘附和入侵,突出了Fap2粘附蛋白的作用.
- 在小鼠模型中,F. animalis殖民了转塑性胃组织,形成生物膜,而F. nucleatum没有殖民.
- 胃代谢增高了Gal-GalNAc和降低了胃酸度,促进了F. animalis的殖民,独立于H. pylori的存在或炎症.
结论:
- 由H. pylori诱导的胃转化形成了F. animalis的二次殖民的利基.
- 这种相互作用表明,H. pylori感染的途径使胃易于被另一种癌症相关微生物,F. animalis. 殖民.
相关概念视频
What is Monogastric Digestion?
74.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
74.9K
Bacterial Phylum Planctomycetes
382
Planctomycetes are a group of morphologically distinct bacteria predominantly classified into two orders: Planctomycetales and Brocadiales. These gram-negative bacteria exhibit unique features, including division by budding and the presence of stalks or appendages. Their cells are often found in rosette arrangements, and they are notable for possessing an S-layer in their cell envelope, which is relatively uncommon among bacteria. Additionally, Planctomycetes frequently exhibit intracellular...
382
Mucosal Barrier of the Stomach
2.0K
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.0K
Bacterial Phylum Firmicutes
867
Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
867
Bacterial Phylum Verrucomicrobiota
481
The phylum Verrucomicrobiota comprises at least four characterized orders, with most species classified within the order Verrucomicrobiotales. Members of this phylum are either aerobic or facultatively aerobic, with the ability to ferment sugars. A notable exception is the genus Methylacidiphilum, which consists of aerobic methanotrophs. Additionally, some Verrucomicrobiota establish symbiotic relationships with protists. These bacteria are widely distributed across various environments,...
481
Bacterial Phylum Bacteroidota
526
The phylum Bacteroidota includes over 700 species classified into four primary orders: Bacteroidales, Cytophagales, Flavobacteriales, and Sphingobacteriales. These gram-negative, non-sporulating rods exhibit saccharolytic capabilities and can be aerobic or fermentative, encompassing obligate aerobes, facultative aerobes, and obligate anaerobes. Many species display gliding motility, though some are nonmotile or use flagella. The genus Bacteroides is well-studied due to its significant role in...
526

