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Updated: Jan 7, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

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一个K27连接的Ubiquitin检查点控制 NOTCH 恒常状态

Behzad Mansoori, Ying Song, Tian Zhang

    bioRxiv : the preprint server for biology
    |December 25, 2025
    PubMed
    概括

    与自相关的蛋白质UVRAG通过招募E3酶ITCH来负面调节NOTCH1信号,促进受体降解. 恢复UVRAG可以抑制NOTCH1驱动的癌症.

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