迷幻药对有非情感性精神病史的人有什么影响? 一个定性研究研究
Haley Maria Dourron1,2, Heith Copes3, Daniel H Grossman4
1Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Frontiers in psychiatry
|December 25, 2025
概括
这项定性研究探讨了非情感性精神病障碍 (NAPD) 患者的迷幻药的使用情况. 研究结果揭示了潜在的好处和挑战,表明了异构的影响,并为未来的迷幻研究提供了信息.
科学领域:
- 心理药理学 心理药理学
- 精神病学是一个精神病学.
- 定性研究是指质量研究.
背景情况:
- 当代迷幻药辅助治疗试验排除了患有精神障碍的个体.
- 之前的调查研究在这个人群中探索了自然主义的迷幻药的使用.
- 缺乏对患有精神疾病的个体的主观迷幻效应的定性检查.
研究的目的:
- 在被诊断患有非情感性精神病障碍 (NAPD) 的个人中对幻觉药物使用的主观经验进行定性调查.
- 在这个人群中探索迷幻药使用的急性和长期感知影响.
- 为心理学干预的安全性和耐受性试验的发展提供信息.
主要方法:
- 进行了半结构化的深入采访,对19名被诊断为NAPD的参与者进行了深入采访,他们曾使用过迷幻药.
- 探测了迷幻药物使用的感知正面和负面影响.
- 通过反射主题分析分析了采访数据.
主要成果:
- 确定了三个主要主题:急性影响 (例如,焦虑) 期间的共同挑战,精神病特有的经历 (例如,对妄想的洞察力,减少自我耻辱),以及急性后/长期影响 (各种好处和缺点).
- 大多数参与者报告了一些好处,但这些好处的持久性差异很大.
- 常见的挑战包括暂时的焦虑,偶尔导致住院治疗.
结论:
- 迷幻药物可能对NAPD患者产生不同的影响,存在风险和潜在益处.
- 这些发现强调了对幻觉药物如何影响NAPD患者的细微研究的需要.
- 结果可以指导设计未来的安全性和耐受性试验的心理干预在这个人群.
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