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Updated: Jan 7, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
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通过冷电子显微镜揭示的T细胞细胞内抗原-1粉样蛋白纤维形成的结构基础

Daigo Inaoka1, Tomoko Miyata2,3, Fumiaki Makino2,3,4

  • 1Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto, Kyoto 606-8502, Japan.

PNAS nexus
|December 25, 2025
PubMed
概括

T细胞细胞内抗原-1 (TIA-1) 类域 (PLD) 通过相分离形成粉样纤维. 低温EM揭示了不稳定的结构以及G355R突变如何破坏纤维细胞的形成,为疾病机制提供了洞察力.

关键词:
粉样蛋白纤维的纤维.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.神经退行性疾病的神经退行性疾病

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