相关实验视频
Updated: Jan 7, 2026

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
24.1K
没有可识别原因的可逆性中央上腺功能衰竭:一个诊断挑战
Rim Masri1, Racha Farhat1, Hiba Jida1
1Endocrinology, Diabetes and Metabolism, Lebanese University Faculty of Medicine, Hadat, LBN.
Cureus
|December 25, 2025
概括
这项研究报告了一例罕见的可逆性中央上腺功能缺陷 (CAI) 病例,患者没有可识别的触发因素. 随着治疗,病情得到了缓解,这凸显了对CAI进行仔细诊断和随访的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
- 案例报告 案例报告
背景情况:
- 可逆性中央上腺功能缺陷 (CAI) 是一种罕见的疾病,涉及由于低上腺皮质激素 (ACTH) 导致皮质醇分泌暂时受损的情况.
- CAI通常与葡萄糖皮质类药物的使用,疾病或药物有关,但也可能发生异常.
- 异常性CAI存在诊断挑战和不必要的长期葡萄糖皮质体治疗的风险.
研究的目的:
- 呈现一种没有可识别触发因素的过渡性CAI病例.
- 强调异形性CAI的诊断和治疗含义.
- 强调CAI的仔细评估和后续行动的重要性.
主要方法:
- 一个45岁的女性的病例报告,怀疑有CAI.
- 实验室检测包括早晨皮质醇和血ACTH水平.
- 垂体MRI和评估其他垂体激素.
- 用皮治疗和随后的监测.
主要成果:
- 患者呈现出低水平的早晨皮质醇 (1.3μg/dL) 和抑制的ACTH (3.13 pg/mL).
- 下垂体MRI没有什么显著的,其他 pituitary 激素在正常范围内.
- 皮治疗导致症状改善,并在三个月内使皮质醇水平正常化.
- 在长期随访期间,观察到上腺功能持续恢复.
结论:
- 过渡性CAI可以发生在异常症上,没有明显的诱发因素.
- 早期识别,适当的治疗和定期重新评估对于管理CAI至关重要.
- 识别异常性CAI可以防止误诊,避免不必要的终身葡萄糖皮质激素治疗.
相关概念视频
Adrenal Gland Disorders
2.8K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.8K
Anatomy of the Adrenal Glands
4.1K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
4.1K
Hormones of the Adrenal Glands
4.4K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
4.4K
Hypothalamic-Pituitary Axis
65.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.3K
Acute Kidney Injury IV: Diagnostic Studies and Prevention
242
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
242
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
2.4K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
2.4K

