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每周母亲暴露于环境颗粒物和先天性心脏病之间的关联

Sun Li¹, Shao Yan¹, Gong Tian¹

¹Suzhou Municipal Hospital, Suzhou Women and Childrens Health Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.

Frontiers in public health

|December 25, 2025

概括

在特定的怀孕周内,母亲暴露于颗粒物10 (PM10) 会增加先天性心脏病 (CHD) 的风险. 对于PM10的临界暴露窗口包括5-12周和18-22周,强调有针对性的预防需求.

科学领域:

环境健康环境健康
生殖流行病学生殖流行病学
心血管病理学心血管病理学

背景情况:

母亲对环境空气污染的暴露越来越多地与先天性心脏病 (CHD) 有关.
对于CHDs在怀孕期间的特定关键暴露窗口仍未得到充分探索.
颗粒物 (PM) 是空气污染的重要组成部分,具有潜在的发展影响.

研究的目的:

评估母亲在怀孕期间暴露于环境颗粒物和心血管疾病风险之间的关联.
为了确定CHD的关键的每周特定暴露窗口.
为了研究各种空气污染物对CHD风险的影响差异.

主要方法:

一项队列研究包括苏州市的19914名孕妇 (2021-2023年).
收集了PM10,PM2.5,NO2,CO和SO2的每周平均暴露数据.
在Cox比例风险模型中使用分布式滞后非线性模型 (DLNM) 来评估暴露-滞后-反应关系.

主要成果:

母亲PM10暴露量增加10μg/m3与妊娠5-12周和18-22周期间心脏病风险增加有关 (p <0.05).
对于PM10最强的关联是在妊娠第5周和第6周观察到的.
在所有妊娠周中,在母亲的PM2.5暴露和心脏病风险之间没有发现显著的关联.

结论:

孕妇在特定怀孕期间 (5-12周和18-22周) 暴露于PM10度升高会增加患心血管疾病的风险.
这项研究确定了怀孕期间对PM10暴露的敏感性的关键窗口.
需要进一步的研究来证实这些发现,并探索潜在的机制.

关键词:

苏州苏州苏州环境中的颗粒物.遗传性心脏缺陷遗传性心脏缺陷遗传性心脏缺陷妊娠期间的暴露敏感的暴露窗口是敏感的暴露窗口.

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