慢性臭氧暴露及其在与年龄有关的白内障发展中的作用:综合分析
Li-Xin Zhou1,2, Jie-Hao Li1,2, Chen-Yan Zeng1,2
1Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
Environment & health (Washington, D.C.)
|December 25, 2025
概括
长期暴露于环境臭氧 (O3) 显著增加患年龄相关白内障的风险,特别是在老年人和2型糖尿病患者中.
科学领域:
- 环境健康 环境健康
- 眼科医生 眼科 眼科
- 流行病学 流行病学
背景情况:
- 环境臭氧 (O3) 是一种具有已知的健康影响的有害空气污染物.
- 有限的研究存在于O3暴露和与年龄相关的白内障之间的关联.
研究的目的:
- 调查长期环境臭氧暴露与中国与年龄相关的白内障发生之间的联系.
- 分析中国长度健康长寿调查 (CLHLS) 的数据,涵盖1998-2018年.
主要方法:
- 利用考克斯的比例危险回归模型来评估在随访前1,2,3年对O3的暴露.
- 使用限制立方线 (RCS) 模型进一步验证该协会.
- 进行子组分析以确定与2型糖尿病和年龄等因素的相互作用.
主要成果:
- 长期暴露于最大每日8小时平均值 (MDA8) O3显示白内障发生的危险比率增加.
- 在随访之前,MDA8 O3暴露的危险比率为1.45 (1年),1.21 (2年) 和1.23 (3年).
- 这种关联在老年人,女性,社会经济地位较低,教育程度较低和2型糖尿病患者中更为强烈.
结论:
- 长期暴露于环境臭氧是与年龄相关的白内障的重要危险因素.
- 2型糖尿病和年龄是加剧O3相关白内障风险的关键相互作用因素.
- 研究结果强调需要改善空气质量,以减轻白内障负担.
相关概念视频
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
Oxidative Cleavage of Alkenes: Ozonolysis
12.6K
In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
12.6K
Chronic Obstructive Pulmonary Disease-I: Introduction
3.5K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.5K
Photoreceptors and Visual Pathways
8.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.6K
Chronic Obstructive Pulmonary Disease
2.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.2K
Aging
561
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
561


