没有艾滋病毒同时感染的mopox患者中中枢神经系统症状:元分析
Junwen Luan1,2, Weimiao Lv1,2, Xiaoyan Wang2
1Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Frontiers in medicine
|December 25, 2025
概括
蒙波克斯病毒 (MPXV) 感染可以导致中枢神经系统 (CNS) 问题,如头痛和肌痛在没有艾滋病毒的人. 这些神经症状在研究的mopox患者群体中约有25%被观察到.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 马波克斯病毒 (MPXV) 与艾滋病毒的同时感染可能会增加神经系统的风险.
- 在没有艾滋病毒的mopox患者中,中枢神经系统 (CNS) 的表现需要特别的调查.
研究的目的:
- 在没有艾滋病毒同时感染的mpox患者中合成和分析中枢神经系统症状.
- 了解MPXV在非艾滋病毒同时感染的人群中的神经影响.
主要方法:
- 在多个数据库 (PubMed,Embase等) 进行系统的文献搜索. 在2023年11月之前.
- 包括队列研究,病例系列,病例对照试验和报告无艾滋病毒的mpox患者神经症状的RCT.
- 使用STATA进行元分析,以汇集中枢神经系统症状得分,以I2统计和Egger测试的出版偏差来评估异质性.
主要成果:
- 包括989名患者在内的14项研究符合纳入标准,大多数被评为中等质量.
- 首要发现的中枢神经系统症状是肌痛 (综合平均得分为0.22),头痛 (0.25),疲劳/喘息 (0.28).
- 敏感性分析证实了稳定的元分析结果,埃格尔的测试表明出版偏差的风险很低.
结论:
- MPXV可以导致神经损伤,包括头痛,肌痛和疲劳/喘息.
- 这些症状影响了大约25% (±3%) 没有HIV同时感染的mopox患者.
- 这些发现突显了mopox的潜在神经影响,无论艾滋病毒状况如何.
关键词:
MPXVMPXV MPXVVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPXVMPX中枢神经系统症状 中枢神经系统症状这是一个元分析.一个MPOX的MPOX.神经系统表现神经系统表现相关概念视频
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