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临床表现 临床表现

Hui Shi1, Yunyi Sun2, Derek B Archer3,4,5,6

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概括
此摘要是机器生成的。

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 睡眠医学 睡眠医学

背景情况:

  • 睡眠健康不佳是阿尔茨海默病和相关痴呆症 (ADRD) 的可修改风险因素.
  • 以前的研究通常依赖于自我报告的睡眠数据或单个睡眠指标.
  • 这项研究检查了九年来客观的,通过动图测量的睡眠健康和认知轨迹.

研究的目的:

  • 为了研究动图测量睡眠健康参数与老年人纵向认知变化之间的关联.
  • 识别可能预测认知衰退的睡眠健康的特定方面.
  • 探索与认知表现相关的睡眠碎片化的潜在新指标.

主要方法:

  • 利用了范德比尔特记忆和衰老项目的553名参与者的数据 (平均年龄为68.5岁).
  • ActiGraph GT9X加速度计测量了10天的睡眠时间,时间,规律性,效率和碎片化.
  • 线性混合效应模型评估了基线睡眠指标与记忆,执行功能和语言的年度变化之间的关联,并对多个共同变量进行了调整.

主要成果:

  • 较长的夜间觉醒与每年记忆和语言功能下降相关.
  • 增加睡眠时间和更大的睡眠不规则与更差的记忆力和更差的执行功能有关.
  • 睡眠时间和不规则性与语言功能每年下降有关;没有观察到因年龄,性别,APOE或认知状态而改变效果.

结论:

  • 睡眠健康不佳的多项措施与记忆和表现的显著9年认知下降有关.
  • 夜间觉醒的持续时间成为睡眠碎片化的潜在新指标.
  • 需要进一步的分子和机制研究,以了解睡眠碎片化和认知衰退之间的联系.