生物标志物 生物标志物
Fuqiang Gao1, Joel Ramirez2,3, Melissa F Holmes1
1Dr. Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
焦点白质超强度 (fWMH) 主要位于深髓血管 (DMV) 附近,这表明与阿尔茨海默病 (AD) 和衰老中的静脉功能不充分有关. 这些fWMH看起来类似于液体,可能表明早期的血管变化.
科学领域:
- 神经成像是一种神经成像.
- 脑血管健康 脑血管健康
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 在MRI上,焦点白质超强度 (fWMH) 的起源仍然不清楚.
- 新出现的证据表明,周血管空间是脑淋巴管,可能受到血管衰老和阿尔茨海默病 (AD) 的影响.
- fWMH可能是AD中静脉原病和淋巴功能障碍的早期指标.
研究的目的:
- 调查fWMH与深髓血管 (DMVs) 的空间共定位.
- 评估fWMH随时间变化的动态变化,以了解它们的性质.
- 探索fWMH,DMVs和AD和衰老中的潜在血管性瘤之间的关系.
主要方法:
- 107名阿尔茨海默症患者和30名对照人群接受了基线和随访MRI扫描.
- 在T2/FLAIR图像上确定了fWMH;在T1,反向T2或SWI序列上可视化了DMV.
- 空间关系被分类为"周血管阳性"或"周血管阴性",并且在1.5年内跟踪fWMH变化.
主要成果:
- 基线fWMH的91.6%是周血管阳性,主要在横向心室沿线的前部和后部和部区域.
- 随访显示,92.8%的fWMH发生了动态变化,其中大多数为周血管阳性.
- 与对照组相比,AD患者的fWMH增加率更高,这些患者的fWMH没有变化.
结论:
- 大多数fWMH位于DMV沿线,并表现出类似流体的动态变化.
- fWMH的进展表明除了缺血之外的作用,可能与深髓静脉中静脉缺陷有关.
- 静脉衰竭可能是AD和老龄化人口中fWMH的重要潜在病理.
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