临床表现 临床表现
Zaldy S Tan1, Nabeel Qureshi1,2, Andrew Hirsch1
1Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
确定阿尔茨海默病和相关痴呆症 (ADRD) 的可修改风险因素至关重要. 一项新的计划发现,高危成年人中睡眠障碍,高胆固醇和低体力活动的高率.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 构成了重大的公共卫生挑战.
- 可修改的医疗和生活方式因素是减少ADRD发病率的潜在目标.
- 塞达斯西奈医院的记忆与健康衰老计划 (MHAP) 旨在通过个性化的风险评估和降低策略来促进大脑健康.
研究的目的:
- 描述参与MHAP计划的个人的人口统计和风险概况.
- 在高危,无症状的成年人群中确定ADRD的常见可修改的风险因素.
- 建立旨在减轻ADRD风险的未来干预措施的基准.
主要方法:
- 一组40岁以上没有认知诊断的Cedars-Sinai医疗中心患者通过电子邮件被招募.
- 参与者填写了关于病史的问卷,并对ADRD风险因素进行了验证调查.
- 用描述性统计数据分析了参与者的人口统计数据和调查答案.
主要成果:
- 该研究包括64名参与者,平均年龄为59.5岁;大多数是女性 (59.4%) 和受过高等教育 (95.3%).
- 高患病率的ADRD危险因素包括睡眠障碍 (75%),家族病史 (69%),体力活动低 (61%),LDL胆固醇升高 (53%).
- 蒙特利尔认知评估 (MoCA) 平均得分为26.1,在延迟回忆,语言和执行功能方面存在显著困难.
结论:
- 个性化风险分析揭示了高风险成年人中可修改的ADRD风险因素的高负担.
- 关键的风险因素包括睡眠障碍,高的LDL胆固醇,不良饮食和久坐不动的生活方式.
- 未来的研究将重点关注风险减轻策略对认知和大脑衰老的有效性.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


