生物标志物 生物标志物
Lina Gomez1, Jonny P Flint1, Jessica Adsett1
1QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在线认知测试有效地测量成年人的大脑健康和阿尔茨海默病风险因素. 这些可访问的评估结果与面对面的评估结果相似,有助于早期检测.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 老年学是一门学科.
背景情况:
- 在线认知测试为传统面对面评估提供了一种灵活,具有成本效益的替代方案.
- 克雷奥斯平台被用来评估中年和老年人的认知功能,这是"前性成像老化研究" (PISA) 的一部分.
- 皮萨的重点是确定阿尔茨海默病的早期生物标志物在一个大的队列.
研究的目的:
- 通过全面的面对面评估,验证Creyos在线认知测试平台的有效性.
- 评估在线认知测量与大脑形态 (皮层骨宽度) 之间的关联.
- 调查认知表现与阿尔茨海默病风险因素和早期生物标志物之间的联系.
主要方法:
- 在141名健康的PISA参与者中验证Creyos平台与面对面的认知测试相比.
- 多变量分析将认知测试表现与MRI扫描中的皮质皮宽度相关联.
- 在一个大样本 (N=2,000) 中,研究认知措施与阿尔茨海默病多基因风险评分 (PRS) 之间的关联.
主要成果:
- 在线认知测试显示,与皮质突宽度的相关性与亲身评估相似.
- 在阿尔茨海默病PRS和执行功能,记忆和视觉空间领域的性能下降之间发现了一个名义上的关联.
- 进一步的分析正在进行中,以探索认知衰退及其与阿尔茨海默病风险的关系.
结论:
- 在线认知评估与面对面的测试相似,用于评估风险人群中的大脑形态.
- 在线测试是大规模研究和预先查阿尔茨海默病风险的有价值,具有成本效益的工具.
- 这种方法可以促进神经退行性疾病的公平早期检测和干预.
相关概念视频
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