基础科学和病原发生学
Xian Wu1,2, Jing Zhang3, Inori Tsuchiya1,2
1Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
遗传和邻居因素共同增加阿尔茨海默病和相关痴呆症 (ADRD) 的风险. 项目响应理论 (IRT) 精确地测量了感知邻居障碍 (PND),揭示了它与不同人群中的APOE ε4的相互作用.
科学领域:
- 遗传学和社会流行病学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 阿尔茨海默病和相关痴呆症 (ADRD) 的风险受到遗传和社会因素的影响.
- 社会因素,如社区特征,可能会改变遗传风险.
- 项目响应理论 (IRT) 与传统的总和方法相比,提供了一种更精确的方法来构建复合社会因素得分.
研究的目的:
- 用IRT模型在不同的人群中构建感知邻居障碍 (PND) 评分.
- 检查PND得分与ADRD中的遗传风险 (APOE ε4) 之间的相互作用.
主要方法:
- 利用我们所有人的数据集,为非西班牙裔白人 (NHW),黑人或非裔美国人 (AA),西班牙裔和亚洲人 (65岁以上) 创建队列.
- 将基于IRT的泛化部分信用模型应用于13项的罗斯-米罗夫斯基感知邻居障碍量表,以获得PND分数.
- 使用后勤回归来评估PND分数和APOE ε4状态与痴呆症的联合关联,调整年龄和性别.
主要成果:
- 在不同族群中,APOE ε4的患病率有所不同,在AA参与者中 (38%) 患病率最高.
- 与NHW和亚洲队伍相比,AA和西班牙裔参与者报告了更大的社区安全缺点.
- 增加的PND得分与更高的痴呆率有关,特别是在具有一个或两个副本APOE ε4的西班牙裔个体中.
结论:
- 在APOE ε4状态,感知邻居障碍和痴呆风险之间存在显著的联合关联.
- 未来的研究应该纳入更广泛的社会措施,额外的遗传因素和特定的ADRD亚型,以阐明基因环境相互作用.
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