基础科学和病原发生学
Davis C Woodworth1, Hannah L Nguyen1, Ali Ezzati1
1University of California, Irvine, Irvine, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
临床标准用于临界主导的与年龄相关的TDP-43脑病变 (LATE) 用尸检结果进行评估. 可能的LATE和可能的LATE很少见,在各组中LATE神经病理变化 (NC) 的比率相似.
科学领域:
- 神经病理学神经病理学
- 神经退行性疾病 神经退行性疾病
- 衰老研究研究 衰老研究
背景情况:
- 最近的临床标准用于临床评估和生物标志物使用临床评估和生物标志物来确定临床主导的与年龄相关的TDP-43脑病变 (LATE).
- 这项研究旨在评估这些标准在鉴定LATE神经病理变化 (NC) 时的有用性.
研究的目的:
- 在尸检时使用神经病理代理来评估诊断LATE的临床标准的有效性.
- 通过运行化的临床标准,在一个大队列中确定LATE-NC的患病率.
主要方法:
- 利用了国家阿尔茨海默氏症协调中心 (NACC) 的数据,包括最后一次访问评估和尸检神经病理学.
- 使用尸检衍生的代理生物标志物 (海马体缩,粉样蛋白-β,) 和临床特征 (渐进性amnestic综合征) 的操作化LATE标准.
- 分析了2438名参与者的数据,比较了不同LATE分类中的LATE-NC率.
主要成果:
- 33.4%的参与者表现出LATE-NC. 在45.7%的病例中发现了渐进性amnestic综合征.
- 很少有参与者符合可能 (41.9%LATE-NC) 或可能LATE (50%LATE-NC) 的标准.
- 与未分类的渐进性amnestic综合征 (p < 0.001) 相比,在可能的LATE与阿尔茨海默病 (AD) 中观察到较高的LATE-NC率.
结论:
- 使用神经病理代理的LATE的操作化临床标准,在NACC队列中很少确定可能和可能的LATE.
- 在所有定义的LATE组中,LATE-NC率相似,这表明目前验证尸检的临床标准的潜在局限性.
- 研究结果强调需要进一步完善LATE诊断标准,特别是在多样化的人口中,考虑到研究在种族,种族和社会经济多样性的局限性.
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