生物标志物 生物标志物
Agathe Vrillon1,2, Ganna Blazhenets3, Yael Rosen Lang4
1Global Brain Health Institute, San Francisco, CA, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
视觉读取和粉样PET的百叶状体量化显示了退伍军人的高度一致性,即使是TBI和PTSD. 视觉阅读可以识别早期的阿尔茨海默氏症疾病模式,这些模式被量化遗漏了.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 创伤性脑损伤 (TBI) 和创伤后应激障碍 (PTSD) 在退伍军人中很常见,可能会影响粉样蛋白PET的解释.
- 评估视觉读取 (VR) 和百叶状体 (CL) 量化之间的一致性对于准确的阿尔茨海默病 (AD) 诊断至关重要.
研究的目的:
- 在美国越南战争退伍军人中评估粉样蛋白PET视觉读取和粉样蛋白量化之间的一致性.
- 确定像TBI和PTSD这样的并发症是否会影响该协议.
主要方法:
- 来自ADNI-DOD队列的粉样蛋白PET扫描 (Florbetapir) 被分析使用神经病学家视觉读取和MRI-free Centiloid量化.
- 不一致的扫描经历了共识审查. 还分析了等离子体生物标志物 (Ab42/40,p-tau217,NfL,GFAP) 和区域SUVR值.
主要成果:
- 在协商一致审查后,达成了高度一致 (91%) (初步:86%, κ=0.67;最终: κ=0.78).
- 认知状态,TBI,PTSD或APOE4状态对协议没有显著的影响.
- 差异主要是VR阳性/定量阴性病例,显示焦点吸收或后部模式,以及更高的血GFAP水平.
结论:
- 粉样蛋白PET视觉读取和粉样蛋白量化显示了在退伍军人中强大的一致性,即使是伴随疾病.
- 视觉读取可以识别早期或非典型的AD模式,仅通过Centiloid量化无法检测到.
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