在 Tilapia (Oreochromis niloticus) 中单次口服后Baicalin的药理动力学
Long-Xun Liu1, Fei Wang1, Zi-Chen Zhao1,2
1School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Fisheries, Hainan University, School of Marine Biology and Collaborative Innovation Center of Marine Science and Technology, Haikou, Hainan, China.
Journal of fish diseases
|December 25, 2025
概括
这项研究研究了鱼中贝卡林的药理动力学,揭示了其快速吸收和在组织中长时间存在. 这些发现支持baicalinalin.
科学领域:
- 水生药理学和毒理学.
- 鱼类健康和疾病管理
- 天然产品药物开发 药物开发
背景情况:
- 巴伊卡林是来自Scutellaria baicalensis的一种黄类物质,它对鱼 (Oreochromis niloticus) 的细菌感染具有治疗潜力.
- 有限的药理动力学数据阻碍了贝卡林在水产养殖中的实际应用.
- 了解贝卡林的吸收,分布,新陈代谢和分泌 (ADME) 对于优化其使用至关重要.
研究的目的:
- 在提拉皮亚的口服后确定贝卡林的药物动力学概况.
- 随着时间的推移,量化各种鱼组织和血中的贝卡林度.
- 为使用贝卡林预防和控制鱼细菌疾病提供科学依据.
主要方法:
- 在32°C的温度下单次口服拜卡林 (12 mg/kg) 给鱼.
- 收集血和组织样本 (脏,胆汁,肌肉,肝脏,大脑) 的时间间隔长达96小时.
- 开发和验证一种高性能液态染色学 (HPLC) 方法,用于量化贝卡林.
- 药物动力学参数的非分区分析.
主要成果:
- 贝卡林呈现出快速吸收,在血,脏和肝脏中观察到双峰现象.
- 峰值度 (Cmax) 和消除半衰期 (t1/2) 在各个组织中各不相同,在大多数组织中发现长时间存在.
- 与抑制度 (AUC/IC50) 和Cmax/IC50比率相对应的度-时间曲线下的面积表明在大多数组织中对Streptococcus agalactiae具有显著的有效性.
结论:
- 巴伊卡林在鱼中表现出有利的药理动力学特性,包括快速吸收和持续的组织度.
- 观察到的药理动力学特征支持贝卡林在预防和控制细菌性疾病,特别是小白链球菌病的潜力.
- 对最佳剂量方案和协同效应的进一步研究可能会增强baicalin在水产养殖中的应用.
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