临床表现 临床表现
Ángela Acosta-Amaya1,2, Salvador Sánchez-Badajos3, Diego Solano-Mendoza4
1Universidad Nacional Autónoma de México, México, EM, Mexico.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
主观认知衰退 (SCD) 和轻度认知障碍 (MCI) 与墨西哥老年人的APOEε4等位基因有关. 携带APOEε4等位基因增加了SCD和MCI的风险,突出显示SCD是阿尔茨海默病连续性早期风险指标.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 老年学是一门学科.
背景情况:
- 主观认知衰退 (SCD) 表示自我报告的认知障碍没有客观缺陷,构成轻度认知障碍 (MCI) 和痴呆症的风险.
- SCD和MCI代表阿尔茨海默病 (AD) 连续性的早期阶段 (2和3).
- APOEε4等位基因是已知的阿尔茨海默病风险因素,其与认知衰退的相互作用需要调查.
研究的目的:
- 为了研究主观认知衰退 (SCD),轻度认知障碍 (MCI) 和墨西哥混血老年人中的APOEε4等位基因状态之间的关系.
- 确定APOEε4载体身份是否会影响该人群中SCD或MCI的风险.
主要方法:
- 一项涉及84名墨西哥混血儿老年人的研究,分为正常认知 (NC),SCD和MCI组 (每组n=28).
- 通过蒙特利尔认知评估 (MoCA) 评估认知功能,通过认知投诉问卷 (CCQ) 评估认知投诉.
- 进行APOE基因型鉴定以确定等位状况;使用SPSS进行的统计分析.
主要成果:
- 在NC和MCI组之间发现了显著的认知性能差异.
- 与NC组相比,在SCD和MCI组中,APOEε4等位基因的频率明显高于NC组.
- 与正常认知相比,携带APOEε4等位基因增加了SCD (OR=5.17) 和MCI (OR=6.60) 的风险.
结论:
- 在墨西哥混血老年人中,SCD,MCI和APOEε4等位基因之间存在关联.
- APOEε4载体的身份对SCD和MCI都有相似的风险,这强调了SCD在AD连续性中的预测因素的作用.
- 对SCD的进一步研究对于早期痴呆症检测和预防策略至关重要.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
516
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
516
Coronary Artery Disease III: Clinical Manifestations
295
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
295
Endocarditis II: Clinical Features of Infective Endocarditis
358
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
358
Heart Failure III: Clinical Manifestations
430
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
430
Gastroesophageal Reflux Disease II: Clinical Features and Management
647
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
647
Hypertension III: Clinical Manifestations and Diagnostic Studies
433
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
433


