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在COVID-19患者中预测肺栓塞的D-二次值:一项回顾性研究
S A A Maulana1, N Mat Hassan2, W Z Wan Ibrahim3
1Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Terengganu, Malaysia. aishahmaulana@unisza.edu.my.
The Medical journal of Malaysia
|December 25, 2025
概括
在COVID-19患者中,D-二次元切断值为2799ng/ml有助于预测肺栓塞 (PE). 这一门有助于临床决策,在这个人群中平衡PE诊断的敏感性和特异性.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 诊断生物标志物 诊断生物标志物
背景情况:
- 肺栓塞 (PE) 是COVID-19患者的一个关键并发症,通常与D-二次体水平升高有关.
- 由于各种疾病因素,COVID-19中PE预测的精确D-二次数值仍然不清楚.
- 了解这种关系对于在COVID-19中及时诊断和管理PE至关重要.
研究的目的:
- 为了确定在COVID-19患者中预测PE的最佳D-二次元切断值.
- 为了评估这个D-二次元切线的灵敏度和特异性.
- 为了确定与COVID-19中PE发生相关的因素.
主要方法:
- 对320名疑似PE的COVID-19患者进行了回顾性分析.
- 计算机断层扫描肺血管造影 (CTPA) 用于PE诊断.
- 对临床因素的分析,包括年龄,性别,种族和D-二次体水平.
主要成果:
- 确定了2799 ng/ml的最佳D-二次元切断值 (AUC为0.744).
- 这种切线显示了PE预测的81%灵敏度和51%特异性.
- 在COVID-19患者中,较高的D-二元水平与PE显著相关 (p=0.001).
结论:
- D-二聚体是COVID-19中PE的有价值的预测生物标志物.
- 已建立的D-二次元切线为临床决策提供了一个实用的工具.
- 建议在多种不同人群中进一步验证.
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