生物标志物 生物标志物
Xuan Chen1, Xue Wang1, Joseph S Reddy1
1Mayo Clinic, Jacksonville, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
针对阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 发现了新的血液生物标志物. 这些新的血液转录组签名反映了大脑的变化,并可能成为未来的诊断工具.
科学领域:
- 神经科学是一个神经科学.
- 基因组学就是基因组学.
- 生物标志物发现发现
背景情况:
- 现有的阿尔茨海默病 (AD) 生物标志物主要针对中枢神经系统病理 (粉样蛋白,蛋白,神经退行).
- 阿尔茨海默病的发病过程复杂而异质,需要在ATN框架之外提供可访问的基于血液的生物标志物.
- 需要血液生物标志物来反映AD的分子大脑变化.
研究的目的:
- 为了识别与AD和轻度认知障碍 (MCI) 相关的血液转录组特征.
- 探索血液基因表达与认知/神经成像测量之间的关系.
- 为了验证血液-大脑分子连接,用于开发新的生物标志物.
主要方法:
- 来自梅奥诊所衰老研究 (MCSA) 和ADNI队列的外周血液转录组数据的分析.
- 基因共同表达网络分析 (WGCNA) 和元分析以确定与疾病相关的模块.
- 在大脑RNAseq队列和丰富分析 (基因本体学,细胞类型) 中验证.
主要成果:
- 特定的血液转录组模块 (M5,M8上调;M1,M10,M13,M16,M21下调) 与AD/MCI状态和认知相关.
- 模块M17与微出血有关;细胞类型丰富确定了免疫细胞参与 (基细胞,单细胞,中性细胞,B细胞,NK细胞).
- 三个模块 (M1,M5,M8) 显示在血液和大脑中保存,M1转录与更好的认知和B细胞代谢活动有关.
结论:
- 识别了与AD/MCI,认知和神经成像相关的血液成绩单和模块.
- 在大脑网络中保存的三个模块代表了外围分子签名,反映了大脑途径的扰乱.
- 优先转录需要进一步研究,作为潜在的新型AD/MCI生物标志物和治疗点.
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